Quinine, a Blocker of Neuronal Cx36 Channels, Suppresses Seizure Activity in Rat Neocortex In Vivo
نویسندگان
چکیده
منابع مشابه
Blocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis
There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We investigated effect of quinine, a specific blocker of Cx36, on the seizure severity...
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15 صفحه اولQuinine suppresses extracellular potassium transients and ictal epileptiform activity without decreasing neuronal excitability in vitro.
The effect of quinine on pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity was studied in vitro using the rat hippocampal slice preparation. Quinine enhanced excitatory post-synaptic potentials and decreased fast- and slow-inhibitory post-synaptic potentials. Quinine reduced the peak potassium rise following tetanic stimulation but did not affect...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2005
ISSN: 0013-9580,1528-1167
DOI: 10.1111/j.1528-1167.2005.00254.x